Recurrence prevention
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Positive FIT? Don’t Skip the Colonoscopy!
Among 45,598 adults with a positive fecal immunochemical test, 17,727 had a colonoscopy within a year. After matching patients on recorded characteristics, colonoscopy completion was associated with lower…
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Radiotherapy was linked to more later (secondary) cancers after colorectal cancer
Across 36 studies, radiotherapy was associated with higher relative risks of uterine cancer, RR 2.65 (95% CI 1.63-3.67), ovarian cancer, RR 2.26 (95% CI 1.30-3.91), and urethral cancer,…
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Updated PHTS surveillance guidance includes colorectal cancer, but evidence remains limited
This ERN GENTURIS expert guideline updates cancer surveillance advice for people with PTEN hamartoma tumour syndrome, including colorectal cancer surveillance. It is based on a literature review and…
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Older surgical patients had 66.2% five-year recurrence-free survival
In this English national cohort, patients over 75 selected for curative colorectal cancer surgery had lower five-year recurrence-free survival than younger patients, largely alongside higher death from both…
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AI assistance detected adenomas in 33.8% versus 30.9% in Lynch surveillance
In this randomised trial across nine specialist centres, adding the CAD EYE artificial intelligence system to high-definition colonoscopy did not significantly increase adenoma detection in people with Lynch…
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ctDNA detection linked to 10-fold and 50-fold higher recurrence risk
A plain-language summary of the α-CORRECT study reports that detectable circulating tumour DNA after surgery or during surveillance was associated with a much higher likelihood of recurrence in…
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Segmental surgery linked to 24% metachronous cancer rate in Lynch syndrome
In this institutional cohort of 450 people with Lynch syndrome and colorectal cancer, 24% of those having segmental resection later developed another colorectal cancer, compared with 5% after…