Meta-analysis
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Adding sidewall node surgery may raise urinary problems after rectal treatment
Across 11 studies involving 2,069 people, adding lateral lymph node dissection to chemoradiotherapy and standard rectal surgery was associated with higher odds of urinary dysfunction, OR 5.94 (95%…
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Starting chemotherapy sooner after surgery was linked to longer survival
Across 11 observational cohort studies involving 72,873 people, starting postoperative chemotherapy more than 8 weeks after surgery was associated with a higher risk of death than starting within…
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Radiotherapy was linked to more later (secondary) cancers after colorectal cancer
Across 36 studies, radiotherapy was associated with higher relative risks of uterine cancer, RR 2.65 (95% CI 1.63-3.67), ovarian cancer, RR 2.26 (95% CI 1.30-3.91), and urethral cancer,…
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Bevacizumab triplet had 0.99 probability of top surgical-conversion ranking
Across seven randomised trials in initially unresectable colorectal liver metastases, bevacizumab plus triplet chemotherapy ranked highest for disease control and conversion to R0-1 surgery. That ranking drew partly…
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First-line immunotherapy reduced progression hazard 39% in MSI-H metastatic colorectal cancer
A meta-analysis of two randomised phase III trials found longer progression-free and overall survival with first-line checkpoint-inhibitor therapy than chemotherapy in MSI-H/dMMR metastatic colorectal cancer. The evidence is…
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Aspirin reduced DFS events 39% in PIK3CA exon 9/20 tumours
A meta-analysis of three randomised trials found fewer disease-free survival events with adjuvant aspirin in colorectal tumours carrying PIK3CA exon 9 or 20 mutations. The ASCOLT trial’s own…
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Colorectal screening uptake among people with HIV pooled at 43%
This meta-analysis combined 22 studies and estimated that 43% of older adults living with HIV had undergone colorectal cancer screening. Detection rates at screening endoscopy were similar to…