Microbiome
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A gut bacterium slowed bowel tumours in mice
In mice genetically prone to intestinal tumours, daily Agathobacter rectalis or its proposed metabolite epigallocatechin reduced tumour measures, while 80 μM epigallocatechin also suppressed colon cancer cells in…
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Stomach bacteria may account for some colorectal cancers worldwide
Across 43 observational studies involving 48,694,403 people, exposure to Helicobacter pylori was associated with 1.59 times higher colorectal cancer risk (95% CI 1.36 to 1.87). A modelling exercise…
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Live gut microbes are being explored alongside colorectal cancer treatment
This review describes live biotherapeutic products, medicines made from living gut microorganisms, as a possible way to influence immunity, microbial balance and treatment response in colorectal cancer. The…
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A gut bacteria chemical slowed colorectal tumors in obesity models
In experimental animal models, oral GABA supplementation and recolonisation with GABA-producing Bacteroides ovatus reduced tumour burden linked to a high-fat diet or obesity-associated colorectal cancer microbiota. The work…
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Tumour bacteria may mark a higher risk of recurrence
In 740 people with stage I to III colorectal cancer, tumours containing Fusobacterium species were associated with shorter recurrence-free survival after surgery, with an adjusted hazard ratio of…
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The saliva microbiome might help detect early-onset colorectal cancer.
In a prospective cohort of 128 people, a machine-learning model using saliva bacteria distinguished people with early-onset colorectal cancer from healthy controls with an AUC of 0.780. This…