Microbiome
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Live gut microbes are being explored alongside colorectal cancer treatment
This review describes live biotherapeutic products, medicines made from living gut microorganisms, as a possible way to influence immunity, microbial balance and treatment response in colorectal cancer. The…
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A gut bacteria chemical slowed colorectal tumors in obesity models
In experimental animal models, oral GABA supplementation and recolonisation with GABA-producing Bacteroides ovatus reduced tumour burden linked to a high-fat diet or obesity-associated colorectal cancer microbiota. The work…
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Tumour bacteria may mark a higher risk of recurrence
In 740 people with stage I to III colorectal cancer, tumours containing Fusobacterium species were associated with shorter recurrence-free survival after surgery, with an adjusted hazard ratio of…
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The saliva microbiome might help detect early-onset colorectal cancer.
In a prospective cohort of 128 people, a machine-learning model using saliva bacteria distinguished people with early-onset colorectal cancer from healthy controls with an AUC of 0.780. This…