Animal study
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Potential new drug target could make oxaliplatin work better
In colorectal cancer cells, patient-derived organoids and mouse models, removing Tex10 made tumors more sensitive to oxaliplatin. Gemcitabine monophosphate bound Tex10 with a reported dissociation constant of 3.51…
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A liver-made RNA package shrank some mouse bowel tumours
In three orthotopic mouse models of colorectal cancer driven by KRAS G12D, G12V or G13D mutations, a treatment designed to make the liver release tumour-targeted RNA packages suppressed…
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A gut bacteria chemical slowed colorectal tumors in obesity models
In experimental animal models, oral GABA supplementation and recolonisation with GABA-producing Bacteroides ovatus reduced tumour burden linked to a high-fat diet or obesity-associated colorectal cancer microbiota. The work…