Retrospective study
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Platelet drugs were linked to lower colorectal cancer mortality
In 334,882 Swedish people with atherosclerotic cardiovascular disease, P2Y12 inhibitor use was not linked to fewer new colorectal cancers, but longer use was associated with lower colorectal cancer…
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A screening program was linked to fewer colorectal cancer deaths
In the Basque Country of Spain, age-standardized colorectal cancer mortality fell from 32.8 to 23.1 deaths per 100,000 people between 2004 and 2024, a 29.6% decline. The fall…
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Chemotherapy was linked to longer time without cancer returning
Among 566 people with stage III colorectal cancer and impaired performance status, adjuvant chemotherapy was associated with longer disease-free survival after matching, HR 0.573 (P=0.003). Oxaliplatin-containing treatment showed…
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Positive FIT? Don’t Skip the Colonoscopy!
Among 45,598 adults with a positive fecal immunochemical test, 17,727 had a colonoscopy within a year. After matching patients on recorded characteristics, colonoscopy completion was associated with lower…
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Tumour bacteria may mark a higher risk of recurrence
In 740 people with stage I to III colorectal cancer, tumours containing Fusobacterium species were associated with shorter recurrence-free survival after surgery, with an adjusted hazard ratio of…
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Older surgical patients had 66.2% five-year recurrence-free survival
In this English national cohort, patients over 75 selected for curative colorectal cancer surgery had lower five-year recurrence-free survival than younger patients, largely alongside higher death from both…
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Severe immune toxicity linked to 48.6% response in MSI-H cancers
In this 1,175-patient retrospective study, people who developed severe immune-related side effects had a higher recorded response rate to immunotherapy. The association is hypothesis-generating, not proof that toxicity…
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84.8% two-year survival after deceased-donor transplant in 35 selected patients
In this six-centre retrospective cohort, 35 people with unresectable colorectal liver metastases received deceased-donor liver transplants. Survival after transplant was high at two years, but the study had…
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Colonoscopy linked to 25% lower CRC hazard at ages 75–79
In a Korean retrospective cohort, adults aged 75 to 79 who had colonoscopy had a lower observed rate of newly diagnosed colorectal cancer than matched adults who did…