meta-analysis
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Bevacizumab triplet had 0.99 probability of top surgical-conversion ranking
Across seven randomised trials in initially unresectable colorectal liver metastases, bevacizumab plus triplet chemotherapy ranked highest for disease control and conversion to R0-1 surgery. That ranking drew partly…
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First-line immunotherapy reduced progression hazard 39% in MSI-H metastatic colorectal cancer
A meta-analysis of two randomised phase III trials found longer progression-free and overall survival with first-line checkpoint-inhibitor therapy than chemotherapy in MSI-H/dMMR metastatic colorectal cancer. The evidence is…
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Aspirin reduced DFS events 39% in PIK3CA exon 9/20 tumours
A meta-analysis of three randomised trials found fewer disease-free survival events with adjuvant aspirin in colorectal tumours carrying PIK3CA exon 9 or 20 mutations. The ASCOLT trial’s own…
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Colorectal screening uptake among people with HIV pooled at 43%
This meta-analysis combined 22 studies and estimated that 43% of older adults living with HIV had undergone colorectal cancer screening. Detection rates at screening endoscopy were similar to…