The CRC Blueprint

My scientific approach to my own cancer – shared with you.

United States

Testing the Effectiveness of the Anti-cancer Drug Pidnarulex (CX-5461), in Combination With Another Anti-cancer Drug Cemiplimab (REGN2810), in Treating Refractory Microsatellite Stable Colorectal Cancer

Phase 2 · randomised · 86 people · 6 sites in United States · Recruiting now

August 7, 2026
A Study Testing SOT109 for the First Time in Patients, to Assess How Safe SOT109 is, How Well it Works, and How the Body Handles it in Patients With Advanced Colorectal Cancer That Can Not be Removed by Surgery or is Metastatic

Phase 2 · randomised · 100 people · 3 sites in 2 countries · Opening soon

August 7, 2026
Evaluation of Co-formulated Pembrolizumab/Quavonlimab (MK-1308A) Versus Other Treatments in Participants With Microsatellite Instability-High (MSI-H) or Mismatch Repair Deficient (dMMR) Stage IV Colorectal Cancer (CRC) (MK-1308A-008/KEYSTEP-008).

Phase 2 · randomised · 302 people · 109 sites in 22 countries · Running, not taking new patients

August 7, 2026
A Study to Evaluate the Adverse Events, and Efficacy of Intravenous (IV) of Telisotuzumab Adizutecan in Combination With IV Oxaliplatin, Fluorouracil, Folinic Acid/Leucovorin, Bevacizumab, Panitumumab in Adult Participants With Metastatic Colorectal Cancer

Phase 2 · randomised · 390 people · 59 sites in 14 countries · Recruiting now

August 7, 2026
Symbiotic-GI-03: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Metastatic Colorectal Cancer

Phase 3 · randomised · 800 people · 285 sites in 17 countries · Recruiting now

August 7, 2026
A Study of Amivantamab Monotherapy and in Addition to Standard-of-Care Chemotherapy in Participants With Advanced or Metastatic Colorectal Cancer

Phase 2 · 225 people · 53 sites in 11 countries · Recruiting now

August 7, 2026
Study of XL092 + Atezolizumab vs Regorafenib in Participants With Metastatic Colorectal Cancer

Phase 3 · randomised · 901 people · 133 sites in 16 countries · Running, not taking new patients

August 7, 2026
Phase 3 Study of MRTX849 With Cetuximab vs Chemotherapy in Patients With Advanced Colorectal Cancer With KRAS G12C Mutation

Phase 3 · randomised · 461 people · 419 sites in 32 countries · Running, not taking new patients

August 7, 2026
A Study to Evaluate the Safety and Efficacy of Two Dose Levels of ONO-4578 With Opdivo®, in Combination With mFOLFOX6 and Bevacizumab Versus Standard of Care in Participants With Non-MSI-H/dMMR, PD-L1 Positive Advanced Colorectal Cancer

Phase 2 · randomised · 144 people · 39 sites in 6 countries · Recruiting now

August 7, 2026
Neoadjuvant Chemotherapy, Excision And Observation vs Chemoradiotherapy For Rectal Cancer

Phase 3 · randomised · 250 people · 113 sites in 2 countries · Recruiting now

August 7, 2026