Recruiting nowPhase 3Randomised
| Registry number | NCT06123156 |
|---|---|
| Recruitment | Recruiting now |
| Phase | Phase 3 |
| Design | randomised, blinded |
| Taking part | 188 people (planned) |
| Who can join | aged 18 Years to 70 Years, men only |
| Run by | University Hospital, Rouen |
| Started | |
| Main results expected | |
| Record last updated |
What is being tested
- Drug Sildenafil
- Other Placebo
What it is measuring
the patient's response
This is the trial's main question — the one it is designed and sized to answer. Anything else it reports is a secondary finding, and secondary findings are far more likely to be chance.
What this trial is trying to do
The researchers think that starting sildenafil, a drug that improves blood flow involved in erections, soon after radiotherapy and rectal surgery may help prevent long-term erectile dysfunction. The trial is testing sildenafil against a placebo in men treated for rectal cancer.
The comparison asks whether early sildenafil can preserve erectile function better than placebo, measured by the patient’s response 12 months after surgery. The hoped-for improvement is less long-term erectile dysfunction, rather than longer cancer control or survival.
Worth knowing: This trial measures sexual function, not whether the cancer is controlled, and applies only to men who have had neoadjuvant radiotherapy and proctectomy.
Written from the trial's own registry entry to explain what the researchers are testing and why. Nothing here is a result — this trial has not reported one — and it is not a view on whether the treatment works or on whether it would suit you.
Phase 3. Compares the treatment against current standard care in a large group. This is the design that changes practice.
How the researchers describe it
This study aims to evaluate the efficacy of erectile rehabilitation with Sildenafil, in men treated with neoadjuvant proctectomy and radiotherapy for rectal cancer, in preventing long-term erectile dysfunction at 12 months post-operatively.
Written by the trial’s sponsor, quoted from its ClinicalTrials.gov record.
What this trial is looking for
- Any genotype
- Rectal
Read automatically from the criteria below, to make the list searchable. It is a summary of what the text mentions, not a decision about whether you qualify — and where the two disagree, the criteria are right and this is wrong.
Who the trial is looking for
Inclusion Criteria
- Men aged 18 to 70
- Patients undergoing surgery for cancer of the lower or middle rectum by total removal of the mesorectum with colorectal or coloanal anastomosis after neoadjuvant radiotherapy, with normal preoperative erectile function (defined by a combined IIEF erectile function domain score of at least 22).
- Nerve-conserving surgery
- Sexually active patient without treatment for erectile function prior to surgery
- Presence of a regular sexual partner (male or female)
- Adult having read and understood the information letter and signed the consent form
- Membership of a social security scheme
Exclusion Criteria
- T4 tumor or tumor requiring extended surgery
- Patients with abnormal erectile function defined by a combined IIEF erectile function domain score of less than 22.
- History of prostate cancer
- Sleep disorders, patients taking sedatives/hypnotics
- Contraindication to SILDENAFIL EG 50 mg, film-coated tablet
- Contraindication to placebo
- Patients already treated with PDE5 inhibitors
- Patients suffering from SARS COV 2*
- Person deprived of liberty by an administrative or judicial decision or person placed under court protection / sub-guardianship or guardianship.
- Any history of illness or psychological or sensory abnormality likely to prevent the subject from fully understanding the conditions required for participation in the prot…
This is an extract. Whether you qualify is decided by the trial team against the full criteria, not by reading this page. Read the full eligibility criteria
Where it is running
Running at 14 sites. Listed in: France.
Individual hospitals, and whether each is currently open, are listed on the registry record. Sites open and close throughout a trial.
Worth asking your oncology team
Being listed here is not a recommendation, and no one page can tell you whether a trial is right for you. These are the questions it raises.
- Is this trial open at a hospital I could realistically travel to?
- Given my stage, my previous treatment and my tumour's molecular profile, would I be eligible?
- What would I be giving up by joining — is the comparison arm the treatment I would otherwise be having?
- What is already known about the safety of what is being tested?
The source
Registry record NCT06123156, registered by University Hospital, Rouen on ClinicalTrials.gov, a public database run by the US National Library of Medicine. The details on this page come from that record and are only ever as current as the sponsor has kept it.
This is a listing of a registered clinical trial, reproduced for information. It is not a recommendation, this site has no connection to the trial or its sponsor, and being listed here says nothing about whether the treatment works. Talk to your own oncology team before pursuing any trial.
This article summarises published research for general information. It is not medical advice, and it is not a substitute for a conversation with your own oncology team, who know your case. Do not start, stop, or change any treatment or supplement on the basis of what you read here.